The Current Standing and Future Prospects of ARTS and Culture in Ethiopia

This research article explores the current state of affairs of arts and culture sector in Ethiopia. An in-depth analysis of various dimensions of art and culture highlights where the country is presently lacking in governance and socio-economic progress in the sector. A qualitative research was carried out to collect primary data. 52 respondents were chosen to be interviewed from Bahir Dar University by the method of quota sampling and the results were analyzed. Secondary data was also analyzed through academic literature from universities in Ethiopia, reports from government and development organizations. Survey results and existing academic literature have guided to single out major hindrances to this sector. In this research it can be confirmed, that the arts and culture sector needs a major intervention in terms of governance and marketing. This research gives out a very structural strategy, based on cultural governance, cultural economics and strategies of new business development as it pillars to support the prosperity of this sector in Ethiopia. The existing academic research provides data on different arts and culture and problems which are specific to a particular region of the country. Whereas this article goes a step further in enforcing the ordinance of cultural governance to the responsible government bodies both locally and nationally and simultaneously highlights how economic progress can be achieved through this sector. Cultural governance as a directive has never been implemented in transition economies and this article will serve as a directive for the future. This article shall be very beneficial for further research in this sector and structuring the work of government bodies, stake holders and the people involved in the sector within Ethiopia

In vitro physicochemical characterization of nanocarriers: a road to optimization

Today's drug delivery scientists and pharmaceutical technologists own unprecedented variety of characterization techniques at their disposal not only to assign precise numerical values to the particle parameters but also to probe their developmental phases as well as their internal environment. Therefore, mechanistic understanding of structure-function relationships of nanotherapeutic systems seems to be a dynamic avowal considering the optimization of final nanoformulation system intended for biodistribution and targeting. This chapter aims to decipher the key in vitro physicochemical parameters in dry state, liquid state, as well as in both dry and liquid states, with the perspective of nanoparticle technology, and the diverse physical and experimental means in which these parameters can be demarcated. Further, an attempt has been made to introduce some best suited specialized techniques that enable to expand the accessible range of information to gain deeper insights into specific nanoplatform properties

In vitro physicochemical characterization of nanocarriers: a road to optimization

Today's drug delivery scientists and pharmaceutical technologists own unprecedented variety of characterization techniques at their disposal not only to assign precise numerical values to the particle parameters but also to probe their developmental phases as well as their internal environment. Therefore, mechanistic understanding of structure-function relationships of nanotherapeutic systems seems to be a dynamic avowal considering the optimization of final nanoformulation system intended for biodistribution and targeting. This chapter aims to decipher the key in vitro physicochemical parameters in dry state, liquid state, as well as in both dry and liquid states, with the perspective of nanoparticle technology, and the diverse physical and experimental means in which these parameters can be demarcated. Further, an attempt has been made to introduce some best suited specialized techniques that enable to expand the accessible range of information to gain deeper insights into specific nanoplatform properties

Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma

Comprehensive multiplatform analysis of 80 uveal melanomas (UM) identifies four molecularly distinct, clinically relevant subtypes: two associated with poor-prognosis monosomy 3 (M3) and two with better prognosis disomy 3 (D3). We show that BAP1 loss follows M3 occurrence and correlates with a global DNA methylation state that is distinct from D3-UM. Poor-prognosis M3-UM divide into subsets with divergent genomic aberrations, transcriptional features, and clinical outcomes. We report change-of-function SRSF2 mutations. Within D3-UM, ElF1AX- and SRSF2/SF3B/-mutant tumors have distinct somatic copy number alterations and DNA methylation profiles, providing insight into the biology of these low- versus intermediate -risk clinical mutation subtypes